The 12th season of Interleague Play between the American League and the National League will begin on Friday, May 16th. Major League Baseball's 2008 schedule features 252 Interleague games to be played in two segments: the first this weekend (May 16th-18th) and the second from June 13th-29th.

This season, American League East Clubs will play primarily against the National League Central; the N.L. East will oppose Clubs from the A.L. West; and the A.L. Central will take on Clubs from the N.L. West.

Interleague Play drew a record total 8,795,939 fans in 2007, averaging an all-time high of 34,905 fans per game. The average 2007 Interleague attendance was 7.3 percent greater than the season's average intraleague attendance of 32,529. Since its inception in 1997, Interleague Play has drawn an average attendance of 33,034 fans, a total that is 11.9 percent higher than the intraleague average of 29,517 during the same span.

The American League posted a 137-115 (.544) record in Interleague Play in 2007, marking the fourth straight season in which the A.L. won the season-series and extending its all-time Interleague lead to 1,387-1,317 (.513). The A.L. posted records of 154-98 in 2006, 136-116 in 2005 and 127-125 in 2004, bringing its Interleague record over the last four years to 554-454 (.550).

In 2007, A.L. Clubs compiled a .281 batting average with 1,352 runs and a 4.37 ERA, compared to the N.L.'s .268 batting average, 1,172 runs and 5.01 ERA. The Detroit Tigers (.314 team batting average, 3.80 team ERA) and the Los Angeles Angels of Anaheim (.330 team batting average, 3.72 team ERA) shared the top Interleague record at 14-4 (.778), followed by the Boston Red Sox at 12-6 (.667). The Chicago Cubs earned the N.L.'s best Interleague mark, going 8-4 (.667). The New York Yankees have baseball's best all-time Interleague record at 113-79 (.589), followed by the Oakland Athletics at 113-81 (.582). The Florida Marlins have the N.L.'s best mark at 105-81 (.565).